A first-half penalty earned Lille a shock 1-0 home victory over holders Real Madrid in the Champions League group phase on Wednesday, ending the 15-times European Cup winners' 14-game unbeaten run in the competition.
Jonathan David converted a penalty three minutes into first-half stoppage time to hand Real, who had not lost in their previous 36 matches in all competitions, their first defeat since January.
The result put Ligue 1 side Lille on three points from two games in the new format of Europe's premier club competition.
Real, who won their opening match against VfB Stuttgart, are also on three points.
Carlo Ancelotti's side started with Kylian Mbappe, who joined from Ligue 1 champions Paris Saint-Germain in June, on the bench after the France captain picked up a muscle injury last week.
Real's Vinicius Jr. had the first chance with a low shot in the sixth minute as the visitors controlled the pace and the second came when Endrick's close-range attempt was blocked by Lucas Chevalier.
Lille went close to opening the scoring after 26 minutes when Andriy Lunin made a spectacular double save to deny David, first from the forward's header, then by tipping away the Canadian's follow-up shot.
Their relentless pressure paid off in stoppage time when Eduardo Camavinga handled Edon Zhegrova's free kick.
A VAR review ensued and David confidently converted the resulting penalty.
The hosts continued to apply pressure in the second half, refusing to sit back and wait as Real enjoyed possession, cutting off the supply to England midfielder Jude Bellingham.
Ancelotti sent Mbappe and Luka Modric on to replace Endrick and Eder Militao and Lille survived a late Real onslaught to hang on for the victory.
Benfica's Kerem Akturkoglu, Angel Di Maria, Alexander Bah and Orkun Kokcu scored in a 4-0 demolition of Atletico Madrid to start their Champions League campaign with two consecutive wins.
A mistake by Atletico's defence helped Akturkoglu open the scoring in the 13th minute and another error ended with a penalty which Di Maria converted.
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Bah extended Benfica's lead with a header from a corner in the 75th minute and Kokcu completed the rout against Diego Simeone's side from the penalty spot after Reinildo Mandava fouled substitute Zewki Amdouni.
Ten-man Juventus twice came from a goal down to stun hosts RB Leipzig 3-2 thanks to Francisco Conceicao's 83rd-minute winner, making it two wins from two matches.
Juve, who were reduced to 10 when keeper Michele Di Gregorio was sent off on the hour for a handball outside the box, fell 1-0 down in the 30th minute when Benjamin Sesko, who had also scored for Leipzig in their opening loss to Atletico Madrid, drilled in off the crossbar.
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The Italians, who had suffered a double blow at the start of the game with the injuries to captain Bremer and Nicolas Gonzalez, recovered after the break.
They levelled through Dusan Vlahovic in the 50th minute but went 2-1 down when Sesko converted a penalty in the 65th to put the hosts back in front.
Serbia striker Vlahovic came to their rescue again three minutes later, curling a left-footed shot into the far top corner to equalise before Conceicao's fine finish completed their comeback.
Ademola Lookman scored one goal and was heavily involved in the other two to drive Atalanta to a 3-0 win over Shakhtar Donetsk in the Champions League on Wednesday as the Italians outclassed their Ukrainian opponents in Gelsenkirchen.
Atalanta have four points from two games, having held Arsenal to a 0-0 draw in their opening match, and Shakhtar remained on one point, after they played out a scoreless draw in the first game against Italian side Bologna.
Atalanta went ahead in the 21st minute when Lookman - scorer of a hat-trick in Dublin during May's Europa League final triumph - curled a cross into the area which found Berat Djimsiti in front of goal and he controlled the ball before poking it past the keeper.
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Atalanta doubled the lead a minute before the break when former Arsenal wing-back Sead Kolasinac squared a pass to Lookman in the middle of the area and the Nigerian struck a first-time shot through the legs of his marker Marlon Gomes into the bottom corner of the net.
The game was all but over as a contest three minutes into the second half after Lookman played the ball out wide to Davide Zappacosta and his cross into the six-yard box was headed home by Raoul Bellanova.
At 3-0, Lookman, who also hit the crossbar in the first half, was taken off with over half an hour to play, his work done for the night and the tie ended with the same scoreline as the last time the sides met in the Champions League in 2019.
AS Monaco came from two goals down to snatch a 2-2 draw away to Dinamo Zagreb at a rain-sodden Maksimir stadium, with Denis Zakaria equalising with a 90th-minute penalty.
Petar Sucic put Dinamo ahead in added time at the end of the first half with a delightful chip over the keeper and the home side doubled their lead in the 66th minute when Martin Baturina struck a powerful shot from outside the area.
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Having been crushed 9-2 at Bayern Munich in their opening game, it looked like the Croatian side would bounce back in style, before Mohammed Salisu headed in from a corner eight minutes later and Dinamo then conceded a late penalty.
Zakaria converted to put Monaco on four points after they beat Barcelona in their first match, and the French side maintained their unbeaten record in all competitions this season.
David Lopez scored Girona's first ever Champions League goal but the Spanish side lost 3-2 at home to Feyenoord in a pulsating contest in which both teams missed a penalty and there were two own goals.
Lopez put Girona ahead midway through the first half, but a Yangel Herrera own goal and a strike from teenager Antoni Milambo swung the contest in the favour of the Dutch visitors.
Ayase Ueda missed a penalty for Feyenoord and Bojan Miovski likewise for Girona, before former Ajax midfielder Donny van de Beek drew the home side level at 2-2.
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That joy was short-lived though as Ladislav Krejci turned the ball into his own net to give Feyenoord the lead again and this time they held on to ensure Girona started their maiden Champions League campaign with consecutive defeats.
A powerful strike from Christos Tzolis earned Club Brugge a 1-0 victory at Sturm Graz.
The Greek forward netted the decisive goal in the 23rd minute, firing into the far corner off the post from the edge of the area following a neat first touch.
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Brugge were prevented from extending their lead by a series of fine saves from goalkeeper Kjell Scherpen early in the second half.
Despite a spirited response from the Austrian hosts, buoyed by an enthusiastic home crowd, they were unable to find an equaliser as Brugge secured a narrow win in the teams' first European meeting
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