Defending champion Novak Djokovic has withdrawn from the French Open due to a knee injury.
The world number one suffered the injury to his right knee during his five-set win over Francisco Cerundolo on Monday.
Djokovic revealed after the match that he would undergo a scan on Tuesday to determine whether he would be able to continue at the tournament.
The MRI scan has subsequently shown the 37-year-old tore the medial meniscus in his right knee, forcing him out of the grand slam.
Roland Garros organisers said: "Due to a torn medial meniscus in his right knee (discovered during an MRI scan performed today), Novak Djokovic, who was supposed to play Casper Ruud in the quarter-finals tomorrow, has been forced to withdraw from the Roland-Garros tournament."
Norwegian seventh seed Ruud will therefore progress straight to the semi-finals.
Djokovic's withdrawal also means Italian Jannik Sinner will become world number one at the end of the tournament.
Sinner became world number one without knowing it as he reached the semi-finals of the French Open for the first time.
While the Italian was beating Grigor Dimitrov in straight sets, Novak Djokovic withdrew from the tournament with a knee injury.
Djokovic's departure means Sinner will rise above the Serbian to the top of the rankings when they are updated on Monday.
The 22-year-old, who is the first man from Italy to be world number one, sank Bulgarian veteran Dimitrov 6-2 6-4 7-6 (3).
"First of all it’s every player’s dream to be number one in the world," he said.
"But in the other way to see Novak retiring for everyone is disappointing, so I wish him a speedy recovery.
"My performance was very solid, especially the first two sets. I’m very happy how I reacted later and happy to be in the semis.
"It’s going to be a huge pleasure to step once again on this court."
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