Scrum-half Craig Casey and centre Alex Nankivell come into the backline.
Jack Crowley will make his 50th appearance for the province at out-half.
Full-back Simon Zebo and wingers Calvin Nash and Shane Daly are named in an unchanged back three.
Seán O'Brien and Nankivell start together in midfield for the first time with Casey and Crowley in the half-backs.
The pack is unchanged for the third game in succession. Jeremy Loughman, Niall Scannell and Stephen Archer pack down in the front row with RG Snyman and captain Tadhg Beirne in the engine room.
Peter O’Mahony, Alex Kendellen and Jack O’Donoghue complete the side.
Eoghan Clarke, Academy prop Mark Donnelly and Oli Jager provide the front row back-up with Tom Ahern and Gavin Coombes completing the forward cover.
Conor Murray, Joey Carbery and Antoine Frisch are the backline replacements.
Munster: Simon Zebo; Calvin Nash, Alex Nankivell, Seán O'Brien, Shane Daly; Jack Crowley, Craig Casey; Jeremy Loughman, Niall Scannell, Stephen Archer; RG Snyman, Tadhg Beirne (capt); Peter O’Mahony, Alex Kendellen, Jack O’Donoghue.
Replacements: Eoghan Clarke, Mark Donnelly, Oli Jager, Tom Ahern, Gavin Coombes, Conor Murray, Joey Carbery, Antoine Frisch.
Connacht, meanwhile, have made three enforced changes from the starting team that beat Dragons for their trip to Thomond.
Peter Dooley, Paul Boyle and captain Jack Carty (above) replace injury absentees Denis Buckley, Cian Prendergast and JJ Hanrahan.
The other changes see Oisín Dowling start alongside Joe Joyce in the second row, while the fit-again Byron Ralston comes onto the left wing.
The remaining forwards are hooker Dave Heffernan, prop Finlay Bealham and flankers Shamus Hurley-Langton and Conor Oliver.
In the backs Matthew Devine is retained at scrum-half, Bundee Aki and Tom Farrell continue their centre pairing, while winger Shane Jennings and full-back Tiernan O'Halloran make up the rest of the back three.
Connacht: Tiernan O’Halloran; Shane Jennings, Tom Farrell, Bundee Aki, Byron Ralston; Jack Carty (capt), Matthew Devine; Peter Dooley, Dave Heffernan, Finlay Bealham; Joe Joyce, Oisín Dowling; Shamus Hurley-Langton, Conor Oliver, Paul Boyle.
Replacements: Dylan Tierney-Martin, Jordan Duggan, Jack Aungier, Niall Murray, Sean Jansen, Caolin Blade, Cathal Forde, Jarrad Butler.
Elsewhere, Alan O'Connor captains Ulster again this week from the second row for their trip to face Scarlets on Saturday (3.05pm).
He is joined by Kieran Treadwell, who makes his return from an injury sustained against Stormers in Cape Town.
The front row sees one change from the home win over Benetton, with Rob Herring returning to the side at hooker.
Herring is joined by Eric O’Sullivan at loosehead prop and Scott Wilson at tighthead prop.
The back row has two changes, as Cormac Izuchukwu starts at blindside flanker, David McCann on the openside and a return to action for Nick Timoney in the number 8 jersey.
Izuchukwu scored his first senior Ulster try in the bonus point victory against Benetton in Round 15.
John Cooney, starts alongside Billy Burns in the half-back partnership for Richie Murphy's side.
The back five has one change from Benetton, with Ethan McIlroy starting on the right wing.
Jacob Stockdale will hope to add to his seven URC tries this season on the left wing.
The centre partnership remains unchanged as Stuart McCloskey is named alongside Will Addison in the centre positions.
Mike Lowry completes the line-up at full-back on his 100th Ulster appearance.
Ulster: Mike Lowry; Ethan McIlroy, Will Addison, Stuart McCloskey, Jacob Stockdale; Billy Burns, John Cooney; Eric O’Sullivan, Rob Herring, Scott Wilson; Kieran Treadwell, Alan O’Connor (capt); Cormac Izuchukwu, David McCann, Nick Timoney.
Replacements: Tom Stewart, Andrew Warwick, James French, Harry Sheridan, Reuben Crothers, Nathan Doak, Stewart Moore, Dave Ewers.
Leo Cullen has made five changes to the Leinster team that beat Northampton Saints in the Champions Cup semi-finals for their clash against the Ospreys at the RDS (7.35pm).
Internationals Andrew Porter, Rónan Kelleher and Tadhg Furlong form the front row, backed up by second rows Ross Molony and Jason Jenkins.
Caelan Doris captains the team from number 8, flanked by Ryan Baird and the incoming Will Connors.
Ross Byrne starts at 10 while Luke McGrath comes into the XV to complete the half-back partnership at scrum-half in place of Jamison Gibson-Park, who is among the replacements.
Jordan Larmour and Jimmy O'Brien will operate from the wings, with Ciarán Frawley at full-back. Robbie Henshaw and Jamie Osborne form the centre partnership.
Leinster: Ciarán Frawley, Jordan Larmour, Jamie Osborne, Robbie Henshaw, Jimmy O'Brien, Ross Byrne, Luke McGrath; Andrew Porter, Rónan Kelleher, Tadhg Furlong, Ross Molony, Jason Jenkins, Ryan Baird, Will Connors, Caelan Doris (capt).
Replacements: Dan Sheehan, Michael Milne, Thomas Clarkson, Jack Conan, Josh van der Flier, Jamison Gibson-Park, Charlie Ngatai, Tommy O’Brien.
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