Danny Welbeck scored one goal and set up another as Brighton and Hove Albion eased to a 3-0 victory at 10-man Everton, a perfect start for the Premier League's youngest ever permanent manager Fabian Huerzeler.
Kaoru Mitoma scored at the back post after excellent work from debutant winger Yankuba Minteh, before Welbeck profited from sloppy play by Everton in midfield to add a second and Simon Adingra added a late third to underline Brighton's superiority.
Boss Huerzeler, 31, will be delighted with a performance in which his side took their chances, in contrast to their hosts who were wasteful In front of goal but also had a penalty decision in their favour controversially overturned by the Video Assistant Referee with the score at 1-0.
Everton right-back Ashley Young was sent off midway through the second half to compound a miserable afternoon for the Toffees, for whom Repubic of Ireland centre-half Jake O'Brien was an unused substitute.
Joelinton's goal earned Newcastle a 1-0 win over promoted Southampton at St James' Park, despite going down to 10 men in the first half.
Fabian Schar was sent off in the 28th minute for retaliating after a foul by Ben Brereton Diaz but the visitors failed to make the most of their numerical advantage, and Newcastle took the lead just before the break.
Southampton keeper Alex McCarthy's poor attempted pass to Jack Stephens was pounced on by Alexander Isak who played the ball across the box and Brazilian Joelinton took one touch before drilling his shot low into the corner of the net.
Southampton had the better of the second half as they piled on pressure in search of an equaliser, but Newcastle held on to take all three points.
Bournemouth attacker Antoine Semenyo rescued a point for his side with a late equaliser as they drew 1-1 at Nottingham Forest.
Forest took the lead in the 23rd minute when defensive midfielder Ryan Yates' close-range shot was parried by goalkeeper Neto and Chris Wood reacted quickly to slot the ball home.
The hosts looked comfortable but Bournemouth equalised in the 86th minute when Semenyo smashed the ball in from close range.
Forest's Brazilian midfielder Danilo was carried off on a stretcher 10 minutes into the game with what appeared to be a serious injury following a collision with Semenyo.
Elsewhere Liverpool forwards Diogo Jota and Mohamad Salah spoiled Ipswich Town's Premier League return and handed new boss Arne Slot a debut 2-0 victory.
And Arsenal eased to a 2-0 win at home against Wolverhampton Wanderers with goals by Kai Havertz and Bukayo Saka getting their latest League title challenge up and running.
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