Goalkeeper Owen Goodman was AFC Wimbledon's hero as the League Two side dumped Premier League Ipswich out of the Carabao Cup on penalties following a 2-2 draw.
Ali Al-Hamadi, who joined Ipswich from Wimbledon in January, scored the opener but Omar Bugiel equalised for the hosts just before half-time.
Mathew Stevens gave the hosts a 2-1 lead in the 56th minute but Conor Chaplin capitalised on a Goodman mistake in the closing stages to send the match to penalties.
Ipswich were on course to go through when Jake Reeves fired over the crossbar.
However, Goodman made two stunning saves from Jack Taylor and Omari Hutchinson before Isaac Ogundere scored the decisive spot-kick.
Jarrod Bowen's late, lucky strike put West Ham into the third round after a 1-0 win over Bournemouth.
A penalty shoot-out was looming at the London Stadium until England forward Bowen found the net two minutes from the end.
A shot from substitute Mohammed Kudus hit the chest of Bowen and flew past Cherries keeper Neto to send the Hammers through.
Sando Tonali made an impressive return from his 10-month betting ban on a night that ended with an awful Taiwo Awoniyi spot-kick as Newcastle knocked Nottingham Forest out on penalties.
The build-up to Wednesday's second-round tie revolved around the 24-year-old midfielder making his first competitive appearance since serving a worldwide suspension for breaching gambling rules in Italy.
Tonali showed flashes of his quality as he stepped out for Newcastle for the first time in 308 days and was involved in the build-up to Joe Willock's opener after just 18 seconds.
Home debutant Jota Silva lashed Forest level early in the second half and the tie ended 1-1 after 90 minutes, with Eddie Howe's visitors triumphing 4-3 on spot-kicks.
Hakon Valdimarsson was the hero for Brentford after his 82nd-minute penalty save earned them a controversial 1-0 win at Colchester.
With England striker Ivan Toney again absent following more speculation over his future this week, Thomas Frank watched Keane Lewis-Potter put the visitors ahead in contentious fashion on the stroke of half-time.
Sky Bet League Two club Colchester wanted a foul for Kevin Schade's push on Aaron Donnelly but nothing was given by referee Paul Howard and it allowed Lewis-Potter to walk in the opener.
Four minutes later, Colchester were given a penalty but Jack Payne's low effort was saved by Valdimarsson with his feet to send the Premier League club through to round three.
Goncalo Guedes struck twice to seal Wolves' spot in the third round with a 2-0 win over Burnley at Molineux.
The hosts were dominant from start to finish and Burnley had keeper Vaclav Hladky to thank for not going a goal down early on before Guedes nudged them in front before the break.
Guedes grabbed his second of the match after 54 minutes to earn Wolves their first competitive win of the season.
Two goals in added time from James Bree and Cameron Archer earned Southampton their first win of the season as they secured a 5-3 triumph away to Cardiff.
Bree's 30-yard screamer was the fourth time the Premier League side had gone ahead and then Archer’s second added an extra bit of security at the end of a superb Carabao Cup second-round match.
Wycombe shocked Championship side Swansea as a first-half strike from Richard Kone earned the visitors a 1-0 win in the second round.
Carabao Cup third-round ties:
Liverpool v West Ham
Manchester City v Watford
Arsenal v Bolton
Manchester United v Barnsley
Wycombe v Aston Villa
Coventry v Tottenham
Walsall v Leicester
Brentford v Leyton Orient
Blackpool v Sheffield Wednesday
Preston v Fulham
Everton v Southampton
QPR v Crystal Palace
Stoke v Fleetwood
Brighton v Wolves
AFC Wimbledon v Newcastle
Chelsea v Barrow
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